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RU486  is a preferred method of abortion among women as it does not involve the use of surgical tools and anesthesia. Medical termination of pregnancy can be performed by using RU486. This method is approved by FDA, hence its safety and efficacy is ensured. RU486 contains 3 tablets of Mifepristone.

Mifepristone acts against progesterone hormone. It is used to terminate pregnancy which is 49 days old. It gets attached to the Progesterone receptor and blocks it, thus inhibiting progesterone from getting attached. It does not set off a true biologic reaction to progesterone; it does, however, have both feeble anti-glucocorticoid and anti-androgenic activity.

Mifepristone also softens and dilates the cervix, leading in placental detachment, boosts uterine lining prostaglandin discharge, augments uterine contractions and improves uterine sensitivity to administered prostaglandin.

RU486 is used for the medical execution of pregnancy up to 49 days of gestation. For use of these pills, pregnancy is dated from the first day of the last menstrual period in a 28 days cycle. These pills induce abortion only if the pregnancy is intrauterine.

The length of pregnancy can be established from menstrual history and by clinical check. Ultrasonographic scan is to be performed, if the length of pregnancy is doubtful, or if ectopic pregnancy is suspected.

Always store RU486 at room temperature in a dry and cool place. Keep this medicine away from children and pets.   

RU486 interacts with drugs like antifungal drugs (Itraconazole or Ketoconazole), Dexamethasone, antiplatelet drugs (Clopidogrel), Ibuprofen, anti-coagulants (warfarin), Erythromycin, Cyclosporine, ergots, etc.  RU486 should not be taken with these drugs as it can lead to severe interactions.

Dosage of RU486 Pill :-

Three 200 mg pills (600 mg) of RU486 are taken in a single oral dose. Then, after two days of administration of RU486 Pill, patient should confirm whether she has successfully aborted or not. Unless abortion has happened and has been established by medical examination or Ultrasonographic scan, the patient takes two 200 mcg pills (400 mcg) of Misoprostol via oral route.

Do not take large amounts of RU486 as it can lead to over-dosing.  In case of emergency, consult your doctor immediately. 

Contraindications of RU486 Pill are:-

  • If your pregnancy is more than 49 days older as its efficacy reduces;
  • If you are using an IUD, then remove it before using RU486;
  • RU486 is not effective if you have an ectopic pregnancy;
  • In cases of adrenal failure, bleeding problems, etc.;
  • If you are taking medicine containing steroids or related compounds.

Side Effects of RU486 Pill are abdominal pain, sickness, nausea, diarrhea, increase in temperature, indigestion, irritation inside the vagina wall, pain in pelvic region, fatigue, etc.

Precautions of RU486 Pill:-

  • RU486 should be taken with caution by woman who are diabetic, have history of migraine, varicose vein disease, high blood pressure or related disorders.
  • Do not take RU486, if you are allergic to Mifepristone or any other ingredient of this medication.
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